Sedazine Mechanism of Action

Pharmacology: Pharmacokinetics: Hydroxyzine is rapidly absorbed and distributed in oral and intramuscular administration, and is metabolized in the liver, the main metabolite (45%) through oxidation of the alcohol moiety to a carboxylic acid, is cetirizine and overall effects are observed within one hour of administration. It has a half-life observed on average of around 7-10 hours in adults, 6-7 hours in children, and 18-21 hours in the elderly, or those with renal insufficiency, with higher concentrations found in the skin than in the plasma. Cetirizine, although less sedating, is non-dialyzable and possesses similar anti-histaminergic properties. In animals, hydroxyzine and its metabolites are excreted via biliary excretion.
Administration in geriatrics differs from the administration of hydroxyzine in younger patients; according to the FDA, there have not been significant studies made (2004), which include population groups over 65, which provide a distinction between elderly aged patients and other younger groups. Hydroxyzine should be administered carefully in the elderly with consideration given to possible reduced elimination.
Similarly, the use of sedating drugs alongside hydroxyzine can cause over-sedation and confusion if administered in large amounts, any form of treatment along side sedatives should be done under supervision of the patient.