Scapho

Scapho

secukinumab

Manufacturer:

Novartis Pharma Stein

Distributor:

Novartis Healthcare
Concise Prescribing Info
Contents
Secukinumab
Indications/Uses
Moderate to severe plaque psoriasis in adults, childn & adolescents from 6 yr who are candidates for systemic therapy. Active psoriatic arthritis in adults, alone or in combination w/ MTX, when the response to previous DMARD therapy has been inadequate. Axial spondyloarthritis (axSpA) w/ or w/o radiographic damage; active ankylosing spondylitis in adults who have responded inadequately to conventional therapy. Adults w/ active non-radiographic axSpA w/ objective signs of inflammation.
Dosage/Direction for Use
SC Plaque psoriasis Adult 300 mg given as 2 inj of 150 mg w/ initial dosing at wk 0, 1, 2, 3, & 4 followed by mthly maintenance dosing. Ped ≥50 kg 150 mg (may be increased to 300 mg); 25-<50 kg 75 mg; <25 kg 75 mg. Each 75 & 150 mg is given as 1 inj; each 300 mg is given as 2 inj of 150 mg w/ initial dosing at wk 0, 1, 2, 3, & 4 followed by mthly maintenance dosing. Psoriatic arthritis 150 mg w/ initial dosing at wk 0, 1, 2, 3, & 4 followed by mthly maintenance dosing. Can be increased to 300 mg given as 2 inj of 150 mg based on clinical response. Patient who are anti-TNFα inadequate responders or w/ concomitant moderate to severe plaque psoriasis 300 mg given as 2 inj of 150 mg w/ initial dosing at wk 0, 1, 2, 3, & 4 followed by mthly maintenance dosing. Ankylosing spondylitis 150 mg w/ initial dosing at wk 0, 1, 2, 3, & 4 followed by mthly maintenance dosing. Can be increased to 300 mg given as 2 inj of 150 mg based on clinical response. Non-radiographic axSpA 150 mg w/ initial dosing at wk 0, 1, 2, 3, & 4 followed by mthly maintenance dosing.
Contraindications
Special Precautions
Hypersensitivity. Patients w/ chronic infection or history of recurrent infection; do not give to patients w/ active TB. Patients w/ inflammatory bowel disease (eg, Crohn's disease & ulcerative colitis).  Do not give concurrently w/ live vaccines. Latex-sensitive individuals (for 1 mL Al pen). Pregnancy & lactation.
Adverse Reactions
Upper resp tract infections (eg, nasopharyngitis). Rhinitis, pharyngitis. Oral herpes, rhinorrhea; diarrhea, urticaria.
MIMS Class
Disease-Modifying Anti-Rheumatic Drugs (DMARDs) / Immunosuppressants / Psoriasis, Seborrhea & Ichthyosis Preparations
ATC Classification
L04AC10 - secukinumab ; Belongs to the class of interleukin inhibitors. Used as immunosuppressants.
Presentation/Packing
Form
Scapho powd for soln for inj 150 mg
Packing/Price
6 mL x 1's
Form
Scapho soln for inj
Packing/Price
1 mL x 1's
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