IV/IM Adult Intra-abdominal infections 2 g IV every 12 hr for 7-10 days.
Moderate to severe pneumonia caused by Strep pneumonia (including those w/ concurrent bacteremia) 1-2 g IV every 12 hr for 10 days.
Hospital-acquired, ventilator-associated or healthcare-associated pneumonia Initially 1-2 g every 8-12 hr.
Moderate to severe uncomplicated skin & skin structure infections caused by Staph aureus or Strep pyogenes 2 g IV every 12 hr for 10 days.
Mild to moderate uncomplicated or complicated UTI (including those associated w/ pyelonephritis &/or w/ concurrent bacteremia) 500 mg-1 g IV/IM every 12 hr for 7-10 days.
Severe uncomplicated or complicated UTI (including those associated w/ pyelonephritis &/or w/ concurrent bacteremia) 2 g IV every 12 hr for 10 days.
Empiric therapy in febrile neutropenic patient 2 g IV every 8 hr for 7 days or until neutropenia resolves.
Childn 2 mth-16 yr (weighing up to 40 kg) Uncomplicated & complicated UTI (including pyelonephritis) 50 mg/kg/dose every 12 hr.
Uncomplicated skin & skin structure infections & pneumonia 50 mg/kg/dose every 12 hr.
Febrile neutropenic patient 50 mg/kg/dose every 8 hr.
Renal impairment Adult Infections Initial dose of 500 mg. Maintenance:
CrCl 30-60 mL/min 500 mg every 24 hr,
11-29 mL/min 500 mg every 24 hr,
<11 mL/min 250 mg every 24 hr. Initial dose of 1 g. Maintenance:
CrCl 30-60 mL/min 1 g every 24 hr,
11-29 mL/min 500 mg every 24 hr,
<11 mL/min 250 mg every 24 hr. Initial dose of 2 g. Maintenance:
CrCl 30-60 mL/min 2 g every 24 hr,
11-29 mL/min 1 g every 24 hr,
<11 mL/min 500 mg every 24 hr.
Empiric therapy in febrile neutropenic patient Initial dose of 2 g. Maintenance:
CrCl 30-60 mL/min 2 g every 12 hr,
11-29 mL/min 2 g every 24 hr,
<11 mL/min 1 g every 24 hr.
Hemodialysis Infections 1 g on 1st day of treatment followed by 500 mg every 24 hr.
Empiric therapy in febrile neutropenic patients 1 g on 1st day followed by 1 g every 24 hr. Administer the same time each day at the completion of procedure on hemodialysis days.
Patient undergoing CAPD Administer usual dose once every 48 hr.
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