Salbo

Salbutamol sulfate

Provides short-acting (4-6 hr) bronchodilation w/ fast onset (w/in 5 min) in reversible airway obstruction in adults, adolescents & childn 4-11 yr. Relief & prevention of asthma symptoms; particularly relief in mild, moderate or severe asthma, provided that reliance on it does not delay the introduction & use of regular inhaled corticosteroid therapy.

Acute asthma symptoms including bronchospasm Adult & childn ≥12 yr 1 inhalation as a single min starting dose. May be increased to 2 inhalations if necessary. Childn <12 yr 1 inhalation. May be increased to 2 inhalations if required. Chronic therapy Adult 2 inhalations up to qid. Childn ≥12 & <12 yr Up to 2 inhalations qid. Prevention of allergen or exercise-induced symptoms Adult & childn ≥12 yr 2 inhalations 10-15 min before challenge. Childn <12 yr 1 inhalation before challenge or exertion. May be increased to 2 inhalations if required. Total daily dose should not exceed 8 inhalations in any 24 hr.

Hypersensitivity. Not to be used to arrest uncomplicated premature labor or threatened abortion.

Discontinue if immediate hypersensitivity reactions occur. Hyperthyroidism, convulsive disorders, myocardial insufficiency, arrhythmias, susceptibility to QT-interval prolongation, HTN & DM; thyrotoxicosis. Hypokalemia in acute severe asthma may be potentiated by concomitant use w/ xanthine derivatives, steroids, diuretics & by hypoxia. Monitor serum K levels. Regular surveillance in patients requiring long-term management w/ bronchodilators. Underlying severe heart disease (eg, ischemic heart disease, arrhythmia or severe heart failure). Consider starting or increasing corticosteroid therapy when there is an increased use of short-acting inhaled β₂-agonist to control asthma symptoms. Discontinue immediately & institute alternative therapy if paradoxical bronchospasm occurs. Check patient's inhaler technique to make sure that inhaler actuation is synchronized w/ inspiration of breath. Advice patient to seek medical advice if therapy fails to give relief for at least 3 hr. Pregnancy & lactation.

Tremor, headache; tachycardia. Palpitations; mouth & throat irritation; muscle cramps.

Potentiated action on CVS w/ MAOI or TCAs, or w/in 2 wk of discontinuation of these agents. Not only block pulmonary effect of β₂-agonists but may produce severe bronchospasm in asthmatic patients w/ β-adrenergic receptor blocking agents. Increased risk of hypokalemia w/ corticosteroids, diuretics or xanthines.

Antiasthmatic & COPD Preparations

R03AC02 - salbutamol ; Belongs to the class of adrenergic inhalants, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.

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