Moderate to severe hepatic impairment (Child-Pugh class B or C).
Special Precautions
Should not be started in patients w/ conc >3x ULN. Monitor conc every 2 wk & may be continued or reintroduced & aminotransferases be checked after 3 days, after further 2 wk then mthly. Childn <18 yr.
Drug metabolized or inhibited by CYP3A4 & CYP2C19. Increased conc w/ ciclosporin. Increased risk of hepatotoxicity & reduced hypoglycemic effect w/ glibenclamide. May reduce plasma conc of some hormonal contraceptives.
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