HIV-PIs. Prolonged QT interval & Torsades de pointes w/ loratadine, trazodone, cisapride, halofantrine, pimozide, disopyramide, fluoroquinolones, macrolides, azole antifungals. Increased serum levels w/ cimetidine. Elevated plasma conc of cyclosporine. HMG-CoA reductase inhibitors. Possible potentiation of bradycardia, sinus arrest & AV block w/ antihypertensives. Increased prothrombin time w/ warfarin & vit K antagonist. Inhibit platelet aggregation w/ clopidogrel. Decreased serum conc w/ rifampin. May cause hypotension, bradycardia & decreased cardiac output w/ fentanyl. Increased conc of lidocaine. Impair metabolism w/ dextromethorphan. Reduced amiodarone levels w/ St. John's wort. Increased plasma levels w/ grapefruit juice. Increased serum conc of digoxin. Antiarrhythmics. Reduced serum levels w/ cholestyramine. Impair metabolism of phenytoin & increased conc of hydantoin. Increased risk of potentially lethal Torsades de pointes w/ vincamine, sultopride, sparfloxacin, erythromycin IV & pentamidine. Elevate risk of ventricular arrhythmias w/ K-wasting diuretics, amphotericin B, cation exchange resins, stimulant laxatives. Increased toxicity of methotrexate. Decreased serum conc w/ rifamycin.