Rosucol Dosage/Direction for Use

The patient should be placed on a standard cholesterol-lowering diet before receiving Rosuvastatin and should continue on this diet during treatment. Rosuvastatin can be administered as a single dose at any time of day, with or without food.
Hypercholesterolemia (excluding Heterozygous familial and non-familial hypercholesterolemia) and Mixed Dyslipidemia (Fredrickson Type IIa and IIb): The dose range for Rosuvastatin is 5 to 20 mg once daily. Therapy with Rosuvastatin should be individualized according to goal of therapy and response. The usual recommended starting dose of Rosuvastatin is 10 mg once daily, initiation of therapy with 5 mg once daily may be considered for patients requiring less aggressive LDL-C reductions or who have predisposing factors for myopathy. For patients with marked hypercholesterolemia (LDL-C > 190 mg/dL) and aggressive lipid targets, a 20-mg starting dose may be considered. The 40-mg dose of Rosuvastatin should be reserved for those patients who have not achieved goal LDL-C at 20 mg. After initiation and/or upon titration of Rosuvastatin, lipid levels should be analyzed within 2 to 4 weeks and dosage adjusted accordingly.
Homozygous Familial Hypercholesterolemia: The recommended starting dose of Rosuvastatin is 20 mg once daily in patients with homozygous FH. The maximum recommended daily dose is 40 mg. Rosuvastatin should be used in these patients as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable. Response to therapy should be estimated from pre-apheresis LDL-C levels.
Dosage in Patients Taking Cyclosporine: In patients taking cyclosporine, therapy should be limited to Rosuvastatin 5 mg once daily.
Concomitant Lipid-Lowering Therapy: The effect of Rosuvastatin on LDL-C and total-C may be enhanced when used in combination with a bile acid binding resin. If Rosuvastatin is used in combination with gemfibrozil, the dose of Rosuvastatin should be limited to 10 mg once daily.
Dosage in Patients with Renal Insufficiency: No modification of dosage is necessary for patients with mild to moderate renal insufficiency. For patients with severe renal impairment (ClCr <30 mL/min/1.73 m²) not on hemodialysis, dosing of Rosuvastatin should be started at 5 mg once daily and not to exceed 10 mg once daily. Or as prescribed by the physician.