Rimactazid-300/Rimactazid-450 Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Per Rimactazid 300 tab INH 150 mg, rifampicin 300 mg. Per Rimactazid 450 tab INH 400 mg, rifampicin 450 mg

Indications/Uses

Pulmonary & extrapulmonary TB.

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Dosage/Direction for Use

Adult >50 kg rifampicin 600 mg + INH 300-400 mg/day, <50 kg rifampicin 450 mg + INH 300-400 mg/day. To be taken once daily.

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Overdosage

View Rimactazid-300/Rimactazid-450 overdosage for action to be taken in the event of an overdose.

Administration

Should be taken on an empty stomach: Take at least 30 min before or 2 hr after meals.

Contraindications

Hypersensitivity to rifamycins &/or INH. History of drug-induced hepatitis; acute liver diseases; peripheral neuritis.

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Special Precautions

Avoid irregular intake & resumption of fixed combination after interruption of therapy. Impaired renal function, liver diseases, low convulsion threshold, undernourishment; epilepsy, alcoholism, gout, DM. Stop treatment in the event of thrombocytopenia, purpura, hemolytic anemia, dyspnea & asthma-like attacks, shock & renal failure. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Increase in liver enzymes, hepatitis, jaundice, leukopenia, eosinophilia, thrombocytopenia, agranulocytosis, anemia, "flu-syndrome" & complications (thrombocytopenia, purpura, hemolytic anemia, dyspnea, asthma-like attacks, shock, renal failure) when resuming treatment after temporary interruption, erosive gastritis, exfoliative dermatitis, Lyell's syndrome, pemphigoid reactions. Peripheral neuropathy, convulsion, psychosis, toxic encephalopathy, rheumatic syndrome, lupus erythematosus-like symptoms, pellagra.

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Drug Interactions

Oral anticoagulants, oral antidiabetics, digitalis, OC, disulfiram, antiarrhythmic agents, ciclosporins, antiepileptic drugs, hydantoins, Ca channel blockers.

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Storage

View Rimactazid-300/Rimactazid-450 storage conditions for details to ensure optimal shelf-life.

Description

View Rimactazid-300/Rimactazid-450 description for details of the chemical structure and excipients (inactive components).

Action

View Rimactazid-300/Rimactazid-450 mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Anti-TB Agents

ATC Classification

J04AM02 - rifampicin and isoniazid ; Belongs to the class of combination drugs used in the systemic treatment of tuberculosis.

Regulatory Classification

Presentation/Packing

Form

Rimactazid -300 tab

Packing/Price

120's (P3,284.65/pack)

Form

Rimactazid -450 tab

Packing/Price

120's (P4,007.52/pack)

Rimactazid-300/Rimactazid-450

rifampicin + isoniazid

Manufacturer:

Sandoz

Distributor:

Zuellig