Hypersensitivity to local anesth of amide type. Acute active diseases of the CNS eg, meningitis, poliomyelitis, intracranial hemorrhage, demyelinating, increased intracranial pressure, cerebral & spinal tumors. Spinal stenosis & active disease (eg, spondylitis, tumor) or recent trauma (eg, fracture) in the vertebral column. TB of the spine. Pyrogenic infection of the skin at or adjacent to the lumbar puncture site. Septicemia. Pernicious anemia w/ subacute combined degeneration of the spinal cord. Coagulation disorders or ongoing anticoagulation treatment. Uncorrected hypotension, cardiogenic or hypovolemic shock. Obstet paracervical block, IV regional anesth (Bier's block) & all IV infusions.