Megaloblastic anemia secondary to vit B12 deficiency. May produce hematologic remission w/ neurologic damage. Large & continuous doses of folic acid may lower the blood conc of vit B12.
Should not be given alone or in conjunction w/ inadequate amounts of vit B12 for the treatment of undiagnosed megaloblastic anemia. Patient w/ folate-dependent tumors.
Anti-convulsants, OCs, anti-TB drugs, alcohol & folic acid antagonists including aminopterin, MTX, pyrimethamine, trimethoprim & sulphonamides which have all been said to produce folate deficiency states.
Sign Out
