History of micturition syncope. Syncopal episodes may occur w/in 30-90 min of the initial dose. Dizziness, light-headedness or fainting may occur when standing up quickly from a lying or sitting position. 1st dose effect: orthostatic hypotension. Vol depletion, restricted salt-intake, advanced age; known susceptibility to developing hypotension; cardiac conditions eg, pulmonary edema due to aortic or mitral stenosis, high-output cardiac insufficiency, right ventricular heart failure caused by pulmonary embolism or pericardial effusion, left ventricular heart failure w/ low filling pressure. Intraoperative floppy iris syndrome (IFIS) during cataract surgery. Do not use on patients w/ reduced urinary outflow or anuria or advanced renal deficiency. Caution in patients w/ impaired liver function & severe hepatic dysfunction. May have a major influence to drive & use machines.
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