Individualized & titrated to desired clinical response. Infusion should not exceed 24 hr.
ICU sedation Adult Initiation: 1 mcg/kg loading infusion over 10 min. Maintenance: 0.2-0.7 mcg/kg/hr. Adjust rate of maintenance infusion to achieve the desired level of sedation.
Procedural sedation Adult Initiation: 1 mcg/kg loading infusion over 10 min. 0.5 mcg/kg loading infusion over 10 min for less invasive procedure eg, ophth surgery. Maintenance: Initially 0.6 mcg/kg/hr & titrate w/ doses ranging from 0.2-1 mcg/kg/hr. Adjust rate of maintenance infusion to achieve the target level of sedation.
Awake fiberoptic intubation in adult patient Initiation: 1 mcg/kg loading infusion over 10 min. Maintenance: 0.7 mcg/kg/hr until the endotracheal tube is secured.
Patient >65 yr Initiation: 0.5 mcg/kg loading infusion over 10 min.
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