Plogrel

Plogrel

clopidogrel

Manufacturer:

Therapharma

Distributor:

Therapharma
Concise Prescribing Info
Contents
Clopidogrel bisulfate
Indications/Uses
Prevention of atherosclerotic events in patients w/ history of recent MI, recent ischemic stroke or established peripheral arterial disease or non-ST segment elevation acute coronary syndrome including patients w/ percutaneous coronary intervention & CABG. Given prophylactically as an alternative to aspirin in patients at risk of thromboembolic disorders.
Dosage/Direction for Use
MI, stroke, peripheral arterial disease & prophylaxis of thromboembolic events 75 mg once daily. Unstable angina/non-Q wave MI Loading dose: 300 mg as a single dose. Continue 75 mg once daily in combination w/ aspirin.
Administration
May be taken with or without food.
Contraindications
Peptic ulcer, intracranial hemorrhage or coagulation disorders. Childn.
Special Precautions
Higher bleeding risk in combination therapy w/ aspirin. Thrombocytopenia purpura. Patients w/ platelet disorder or increased bleeding eg, peptic ulcer, trauma, surgery except in patients w/ cardiac stents & no complete antiplatelet therapy. Hepatic & renal impairment. Discontinue use 5 days prior to elective surgery. Pregnancy & lactation.
Adverse Reactions
Drug Interactions
Aspirin, NSAIDs, anticoagulants. Phenytoin, tamoxifen, tolbutamide, warfarin, torsemide & fluvastatin. Bupropion, statins & ciclosporin. Clarithromycin, erythromycin, troleandomycin.
MIMS Class
Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)
ATC Classification
B01AC04 - clopidogrel ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.
Presentation/Packing
Form
Plogrel FC tab 75 mg
Packing/Price
50's (P1,896.36/pack)
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