Na & fluid retention, CHF, K loss, hypokalemic alkalosis, HTN, increased Ca excretion; muscle weakness, steroid myopathy, loss of muscles mass, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral & humeral heads, pathological fracture of long bones, tendon rupture & post inj flare (intra-articular); peptic ulcer w/ possible perforation & hemorrhage, small & large bowel perforation, pancreatitis, abdominal distension, ulcerative esophagitis, dyspepsia, esophageal candidiasis; impaired wound healing, thin fragile skin, petechiae & ecchymoses, erythema, striae, telangiectasia, acne, increased sweating, possible suppression of skin tests, burning or tingling in the perineal area (IV), allergic dermatitis, urticaria, angioneurotic edema & hypo- or hyper-pigmentation; convulsions, increased intracranial pressure w/ papilloedema, vertigo, headache, psychic disturbances (eg, euphoria, psychological dependence, depression, insomnia); menstrual irregularities, amenorrhea, development of Cushingoid state, suppression of growth in childn & adolescents, secondary adrenocortical & pituitary unresponsiveness (in times of stress), decreased carbohydrate tolerance, latent DM, increased insulin requirement or oral hypoglycemic agents in diabetes, hirsutism; opportunistic infections, recurrence of dormant TB; posterior subcapsular cataracts, IOP, papilloedema, corneal or scleral thinning, exacerbation of ophth viral disease, glaucoma, exophthalmos. -ve nitrogen balance due to protein catabolism, -ve Ca balance; hypertrophic cardiomyopathy in low birth-wt infants; hypersensitivity (anaphylaxis), leucocytosis, thromboembolism, wt gain, increased appetite, nausea, malaise, hiccups & sterile abscess; acute adrenal insufficiency, hypotension & death.
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