Adult/Elderly Active duodenal ulcer, active benign gastric ulcer & anastomotic ulcer 10 or 20 mg once daily in the morning.
Erosive or ulcerative GERD 10 or 20 mg once daily for 4-8 wk. Doses of 10 or 20 mg bid may be administered for another 8 wk in reflux esophagitis patient who are not responding to the usual dose of PPIs. However, a dose of 20 mg bid should only be administered to patient w/ severe mucosa injury.
GERD maintenance 10 or 20 mg once daily depending upon patient response. For the maintenance therapy when PPI treatment is ineffective, dose of 10 mg bid may be administered.
Symptomatic GERD moderate to very severe 10 mg once daily for patient w/o esophagitis. If symptom control has not been achieved after 4 wk, the patient should be further investigated.
Zollinger-Ellison syndrome & other pathological hypersecretory conditions Initially 60 mg daily, increase up to 100 mg once daily or 60 mg bid.
Eradication of H. pylori in patient w/ PUD 10 or 20 mg + clarithromycin 500 mg & amoxicillin 1 g all bid for 7 days.
Adult Prevention of gastric & duodenal ulcer recurrences associated w/ low-dose aspirin therapy 10 mg once daily.
Adolescent ≥12 yr 20 mg once daily for 8 wk.
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