Tab Adult & adolescents ≥12 yr Reflux oesophagitis 1 tab once daily may be increased to 2 tabs daily.
Adult Eradication of H. pylori in combination w/ two appropriate antibiotics Depending upon the resistance pattern, the following combinations may be given a) 1 tab bid + 1000 mg amoxicillin bid + 500 mg clarithromycin bid; b) one tab bid + 400-500 mg metronidazole (or 500 mg tinidazole) bid + 250-500 mg clarithromycin bid; c) one tab bid+ 1000 mg amoxicillin bid + 400-500 mg metronidazole (or 500 mg tinidazole) bid. Combination therapy is implemented for 7 days may be prolonged for up to total of 2 wk.
Gastric & duodenal ulcer 1 tab daily, may be increase up to 2 tab daily.
Zollinger-Ellison-syndrome & other pathological hypersecretory conditions Initially 80 mg daily, may be titrated as needed up to 160 mg.
Patients w/ hepatic impairment 20 mg daily.
IV Reflux esophagitis, gastric & duodenal ulcer 40 mg/day.
Zollinger-Ellison syndrome & other pathological hypersecretory conditions Initially, 80 mg/day, can be titrated as needed.
Severe liver impairment Max: 20 mg/day.
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