Patients w/ history of constipation or signs of subacute intestinal obstruction. Patients who are likely to develop QT interval prolongation including those w/ personal or family history of QT prolongation, electrolyte abnormalities, CHF, bradyarrhythmias, conduction disturbances & taking anti- arrhythmic agents or other medicinal products that lead to QT prolongation or electrolyte abnormalities. Correct hypokalemia & hypomagnesemia prior to administration. Serotonin syndrome. Not to be used to prevent or treat nausea & vomiting in the days following chemotherapy if not associated w/ another chemotherapy administration. May affect ability to drive & use machines. Pregnancy. Discontinue breastfeeding during therapy.
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