Oxtimon

Oxtimon

oxytocin

Manufacturer:

Rotexmedica GmbH

Distributor:

Duopharma Trade (Phils)
Concise Prescribing Info
Contents
Oxytocin
Indications/Uses
Induction of labour for medical reasons; stimulation of labour in hypotonic uterine inertia; during cesarean section following the delivery of the child. Prevention & treatment of postpartum uterine atony & hemorrhage. Adjunctive therapy for the management of incomplete, inevitable or missed abortion in early stages of pregnancy.
Dosage/Direction for Use
Induction or enhancement of labor 10 IU IV drip infusion added to 1 L of physiologic electrolyte soln. 5% dextrose soln may be used as diluent for patients in whom infusion of NaCl must be avoided. Initial infusion rate: 1-4 mU/min (2-8 drops/min). May be gradually increased at ≥20 min interval until contraction pattern similar to normal labor is established. Max rate: 20 mU/min (40 drops/min). Caesarean section 5 IU by slow IV inj immediately after delivery. Prevention of postpartum hemorrhage 5 IU slow IV after delivery of placenta. Treatment of postpartum uterine hemorrhage 5-10 IU IM or 5 IU slow IV, followed in severe case by 5-20 IU IV infusion in 500 mL of non-hydrating diluent. Incomplete, inevitable missed abortion 5 IU IM or slow IV, followed by 20-40 mU/min IV infusion or higher if necessary.
Contraindications
Hypersensitivity. Hypertonic uterine contractions, mechanical obstruction to delivery, fetal distress; significant cephalopelvic disproportion, fetal malpresentation; placenta previa & vasa previa, placental abruption, cord presentation or prolapse, overdistention or impaired resistance of the uterus to rupture as in multiple pregnancy, polyhydramnios, grand multiparity & presence of uterine scars resulting from major surgery including classical cesarean section. Prolonged period in patients w/ oxytocin-resistant uterine inertia, severe pre-eclamptic toxemia or severe CV disorder.
Special Precautions
Administer as IV infusion only for labor induction & enhancement. Monitor fetal heart rate & uterine motility. Presence of borderline cephalopelvic disproportion, secondary uterine inertia, mild to moderate degrees of pregnancy-induced HTN or cardiac disease & patients >35 yr or w/ history of lower-uterine-segment caesarian section. Avoid tumultuous labor in case of fetal death in utero &/or presence of meconium-stained amniotic fluid. May cause water intoxication associated w/ hyponatremia. Avoid rapid IV inj in the prevention of treatment of uterine hemorrhage. Concomitant use w/ prostaglandins, inhalation anesth (eg, cyclopropane or halothane), sympathomimetic vasoconstrictor agents. Incompatible w/ soln containing Na metabisulfite as a stabilizer.
Adverse Reactions
Uterine spasm (low dose). High doses: Uterine overstimulation causing fetal distress, asphyxia & death, or may lead to hypertonicity, tetanic contractions, soft tissue damage or uterine rupture. Water intoxication w/ maternal & neonatal hyponatremia. Acute short-lasting hypotension accompanied w/ flushing & reflex tachycardia in rapid IV bolus inj.
Drug Interactions
May potentiate the uterine action of prostaglandins & analogues & vice versa. Potentially arrhythmogenic w/ QT-prolonging drugs. May diminish uterotonic effects & cause cardiac rhythm disturbances w/ inhalation anesth (eg, cyclopropane, halothane, sevoflurane, desflurane). May enhance vasopressor effects of vasoconstrictors & sympathomimetics. May potentiate pressor effects of sympathomimetic vasoconstrictors.
MIMS Class
Drugs Acting on the Uterus
ATC Classification
H01BB02 - oxytocin ; Belongs to the class of oxytocin and analogues. Used in posterior pituitary lobe hormone preparations.
Presentation/Packing
Form
Oxtimon soln for inj 10 IU/mL
Packing/Price
1 mL x 10 × 1's
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