Nirva Contraindications

Known hypersensitivity to clozapine or any ingredient of the product; In patients with myeloproliferative disorders, uncontrolled epilepsy, paralytic ileus, or a history of clozapine-induced agranulocytosis or severe granulocytopenia.
In patients who are unable to undergo regular blood tests.
History of toxic or idiosyncratic granulocytopenia/agranulocytosis (with the exception of granulocytopenia/agranulocytosis from previous chemotherapy).
Impaired bone marrow function.
Alcoholic and other toxic psychoses, drug intoxication, comatose conditions.
Circulatory collapse and/or CNS depression of any cause; Severe renal or cardiac disorders (e.g., myocarditis).
Active liver disease associated with nausea, anorexia or jaundice; progressive liver disease, hepatic failure.
Concomitant use with long-acting depot antipsychotics (which have myelosuppressive potential) since these cannot be rapidly removed from the body in situations where this may be required (e.g., Neutropenia). (See Interactions).