Decreased exposure w/ nortryptiline. Decreased fluoxetine exposure. Increased
BP effect w/ diuretics, β-blockers, ACE inhibitors, A1-antagonists,
other Ca antagonists, α-adrenergic blocking agents PDE5 inhibitors,
α-methyldopa. Higher AUC of zidovudine. Elevated plasma conc & prolonged action w/ grapefruit juice. Tab: Accelerated metabolism leading to reduced efficacy w/ rifampicin. Reduced bioavailability w/ antiepileptics eg, phenobarb, phenytoin or carbamazepine. Increased plasma conc w/ macrolides (eg, erythromycin), anti-HIV PI (eg, ritonavir), nefazodone, quinupristin/dalfopristin, cimetidine, valproic acid. Increased systemic bioavailability w/ azole anti-mycotics eg, ketoconazole. Soln for infusion: Alcohol-incompatible drugs.
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