150-600 mg/day in 2 or 3 divided doses. Epilepsy Initially 150 mg/day as 2 or 3 divided doses, then may be increased to 300 mg/day after 1 wk. Max of 600 mg/day. GAD 150-600 mg as 2 or 3 divided doses. Initially 150 mg/day, then may be increased to 300 mg/day after 1 wk. Following an additional wk, increase dose to 450 mg/day. Max of 600 mg/day.
Diabetic patients. Discontinue immediately if symptoms of angioedema or upper airway swelling occur. Dizziness, somnolence, loss of consciousness & mental impairment; blurred vision, renal failure, w/drawal of concomitant antiepileptic medicinal products. W/drawal symptoms after discontinuation. Elderly CV compromised patients. Increased incidence of adverse reactions, CNS reactions & somnolence in treatment of central neuropathic pain due to spinal cord. Suicidal ideation & behavior. Reduced lower GIT function (eg, intestinal obstruction, paralytic ileus, constipation) w/ medications that have the potential to produce constipation eg, opioid analgesics. History of substance abuse; encephalopathy.
May potentiate the effects of ethanol & lorazepam. Resp failure & coma w/ other CNS depressant medicinal products. Additive in the impairment of cognitive & gross motor function w/ oxycodone.
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