50 mg once daily, may be increased to 100 mg daily as a single dose or in 2 divided doses. Elderly >76 yr & patient w/ moderate to severe renal impairment (CrCl <20 mL/min) or intravascular fluid depletion Initially 25 mg once daily.
May potentiate antihypertensive effects w/ other agents that lower BP. Additive hyperkalemic effect w/ supplements, K-sparing diuretics or other drugs causing hyperkalemia. May increase risk of renal impairment (particularly those who are adequately hydrated) & may also attribute to hypotensive effect w/ NSAIDs. Interactions may occur w/ drugs affecting CYP450 isoenzymes.
Sign Out
