Nebil Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing Brand Resources

Concise Prescribing Info

Contents

Nebivolol HCl

Indications/Uses

Treatment of essential HTN & stable, mild & moderate CHF in addition to standard therapies in elderly patients ≥70 yr, alone or in combination w/ other antihypertensive drugs.

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Dosage/Direction for Use

Adult 5 mg once daily. Max dose: 10 mg once daily. Elderly & renal insufficiency Initially 2.5 mg once daily, may be increased to 5 mg. Hepatic insufficiency 2.5 mg once daily.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity. Severe hepatic insufficiency. Acute heart failure, cardiogenic shock or episodes of heart failure decompensation requiring IV inotropic therapy. Sick sinus syndrome including SA block; 2nd & 3rd degree heart block (w/o pacemaker); history of bronchospasm & bronchial asthma; untreated pheochromocytoma; metabolic acidosis; bradycardia (heart rate <60 bpm); hypotension (systolic BP <90 mmHg); severe peripheral circulatory disturbances. Rare hereditary problems of galactose intolerance, Lapp-lactase deficiency or glucose-galactose malabsorption.

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Special Precautions

Concomitant use of anesth. Patients w/ compensated CHF, peripheral vascular disease, history of psoriasis & those on dialysis. May mask symptoms of hypoglycemia in diabetic patients. Abrupt w/drawal may lead to transitory worsening of heart failure. Pregnancy & lactation. Elderly >75 yr.

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Use In Pregnancy & Lactation

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Adverse Reactions

Headache, dizziness, paresthesia, dyspnea, constipation, nausea, diarrhea, tiredness, edema; bradycardia.

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Drug Interactions

Ca antagonists (verapamil & diltiazem), antiarrhythmics eg, disopyramide. Increased risk of bradycardia w/ digitalis glycosides. Catecholamine-depleting drugs eg, reserpine, guanethidine; clonidine. CYP2D6 inhibitors (eg, quinidine, propafenone, fluoxetine, paroxetine). Increased plasma levels w/ cimetidine. Decreased AUC & C_max of sildenafil.

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Storage

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Description

View Nebil description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Beta-Blockers

ATC Classification

C07AB12 - nebivolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.

Regulatory Classification

Presentation/Packing

Form

Nebil tab 2.5 mg

Packing/Price

14's (P14.5/tab)

Form

Nebil tab 5 mg

Packing/Price

14's (P19.8/tab)

Nebil

nebivolol

Manufacturer:

Getz Pharma

Distributor:

Getz Pharma