Monotherapy 1st 3 administrations: 60 mg/m
2 once wkly, subsequently beyond the 3rd administrations, increase the dose to 80 mg/m
2 once wkly except in patients for whom the neutrophil count dropped once <500/mm
3 or more than once between 500 & 1,000/mm
3 during the 1st 3 administrations at 60 mg/m
2. Dose modification: For any administration planned to be given at 80 mg/m
2, if the neutrophil count is <500/mm
3 or between 500 & 1,000 mm
3 more than once, the administration should be delayed until recovery & the dose reduced from 80-60 mg/m
2/wk during the 3 following administrations. Increase the dose from 60-80 mg/m
2/wk if the neutrophil count did not drop <500/mm
3 or more than once between 500 & 1,000/mm
3 during the last 3 administrations given at 60 mg/m
2 according to the rules previously defined for the 1st 3 administrations.
Combination chemotherapy Dose & treatment regimen should be adjusted according to treatment protocol.
BSA of ≥2 m2 Total dose must not exceed 120 mg/wk (60 mg/m
2 dosage) or 160 mg/wk (80 mg/m
2).
Patient w/ mild liver impairment (bilirubin <1.5 x ULN & AST &/or ALT 1.5-2.5 x ULN) 60 mg/m
2/wk.
Patient w/ moderate liver impairment (bilirubin from 1.5-3 x ULN regardless of the ALT & AST) 50 mg/m
2/wk.