Hypersensitivity to the active substances, to other sulfonamides, to dihydropyridine derivatives or to any of the excipients; severe renal failure (creatinine clearance below 30 mL/min); hepatic encephalopathy or severe impairment of liver function; hypokalemia; lactation; severe hypotension; shock (including cardiogenic shock); obstruction of the outflow tract of the left ventricle (e.g., high grade aortic stenosis); hemodynamically unstable heart failure after acute myocardial infarction.
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