Do not use for intra-articular continuous infusion. Poor general condition due to aging or compromised factors; patients treated w/ anti-arrhythmic drugs class III (eg, amiodarone). Cardiac arrest (rare) reported. Severe liver disease. May lead to hypotension & bradycardia. Avoid prolonged use. Administer to patients w/ acute porphyria. May impair ability to drive or operate machinery. Pregnancy & lactation.
Concomitant use w/ other or related amide-type local anesth eg, certain arrhythmics (eg, lidocaine & mexiletine). Increased plasma conc w/ strong inhibitors of CYP1A2 eg, fluvoxamine & enoxacin.
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