Mytoxid

Mytoxid

mitomycin

Manufacturer:

Korea United Pharma

Distributor:

Qualimed
Concise Prescribing Info
Contents
Mitomycin
Indications/Uses
Improve subjective & objective symptoms in a wide range of neoplastic conditions including chronic lymphatic & myelocytic leukemia; gastric, colonic, rectal, pulmonary, pancreatic, uterocervical cancer, hepatocarcinoma, mastocarcinoma; head, neck & bladder tumor.
Dosage/Direction for Use
IV Intermittent administration 4-6 mg daily, once or twice a wk. Continuous administration 2 mg daily. Massive intermittent administration 10-30 mg daily at 1-3 wk intervals. Concomitant administration w/ other antineoplastics 2-4 mg daily every 1-2 wk. Arterial route Administration to specific cases 2-10 mg into the pleural & peritoneal cavities. Prevention of recurrent bladder tumor 4-10 mg instilled into the bladder once a day or every 2 days. Treatment of bladder tumor 10-40 mg instilled into the bladder once a day. Max: 30 mg IV.
Contraindications
Hypersensitivity. Patients w/ thrombocytopenia, coagulation disorder or increased bleeding tendencies.
Special Precautions
Patients w/ hepatic failure, renal impairment & bone marrow suppression. Observe for evidence of renal toxicity. Serum creatinine >1.7 mg/dL. Leukopenia. Pregnancy & lactation. Childn.
Adverse Reactions
Thrombocytopenia, leukopenia, hemorrhage, anemia; renal failure, HTN, edema, hematuria, albuminuria; anorexia, nausea, vomiting, stomatitis, gastritis, diarrhea; necrotic cystitis & urethrostenosis.
Drug Interactions
Concomitant combination w/ other malignant antitumor agent or irradiation, vinca alkaloids (eg, vincristine sulfate, vinblastine sulfate & vindesine sulfate), phenytoin, yellow fever vaccine, doxorubicin, uratic nitrogen. Increased effect w/ barbiturates.
MIMS Class
Cytotoxic Chemotherapy
ATC Classification
L01DC03 - mitomycin ; Belongs to the class of other cytotoxic antibiotics. Used in the treatment of cancer.
Presentation/Packing
Form
Mytoxid powd for inj 10 mg
Packing/Price
1's
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