Prophylaxis of acute transplant rejection in patients receiving allogeneic renal transplants in combination w/ ciclosporin for microemulsion & corticosteroids.
Not to be used in patients w/ hereditary deficiency of hypoxanthine-guanine phosphoribosyl-transferase. Increased risk of developing lymphomas & other malignancies particularly of the skin. Over-suppression of the immune system w/ increased susceptibility to infection. Viral reactivation in patients infected w/ HBV or HCV; monitor patients infected w/ hepatitis B or C for clinical & lab signs of active HBV or HCV infection. Risk of progressive multifocal leukoencephalopathy & pure red cell aplasia. Patients w/ active serious digestive system disease. Report any sign of bone marrow depression. Perform CBC on a regular basis. Avoid live-attenuated vaccines. Male patient should use condoms &/or partner should use highly effective contraception. Not to be used during pregnancy & lactation. Childn.
Not recommended in concomitant use w/ azathioprine, live vaccines. Increased plasma conc w/ aciclovir. Decreased absorption w/ Mg & Al hydroxide antacids; ganciclovir. Tacrolimus. Potential to reduce efficacy w/ cholestyramine or drugs that interfere w/ enterohepatic circulation. OC's.
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