Hypersensitivity to other nitrates/nitrites. Acute circulatory failure associated w/ marked hypotension (shock & states of collapse), angle-closure glaucoma, functional or organic GI hypermotility or malabsorption syndrome; increased intracranial pressure eg, head trauma or cerebral hemorrhage; myocardial insufficiency due to obstruction eg, presence of aortic or mitral stenosis or of constrictive pericarditis. Obstructive hypertrophic cardiomyopathy, pericarditis, cardiogenic shock, postural or orthostatic hypotension, severe anemia. Concomitant use w/ PDE-5 inhibitors (eg, sildenafil, tadalafil, vardenafil).