Duodenal ulcer 20 mg once daily for 2-4 wk. Patient w/ duodenal ulcer refractory to other treatment regimens 40 mg once daily may be effective. Maintenance: 10-20 mg once daily. Gastric ulcer & reflux oesophagitis 20 mg once daily for 4-8 wk. Patient w/ gastric ulcer or reflux oesophagitis refractory to other treatment regimens 20 mg once daily may be effective. Patient w/ severe or symptomatic recurrent reflux oesophagitis Continue treatment at 20 mg once daily. Zollinger-Ellison syndrome Initially 60 mg once daily. Patient w/ severe disease Maintenance: 20-120 mg daily. Doses >80 mg daily should be divided into bid regimens. Hepatic impairment 20 mg daily.
View ML-Gacid overdosage for action to be taken in the event of an overdose.
Administration
Should be taken on an empty stomach: Take at least 1 hr before meals. Swallow whole, do not chew/crush. For patients w/ difficulty swallowing, cap may be carefully opened & entire contents sprinkled in a spoonful of applesauce. Swallow drug/food mixt w/o chewing immediately after prep. Drug/food mixt should not be stored for future use.
Prolonged elimination of medicines metabolised by oxidation in the liver eg, warfarin, diazepam & phenytoin. May increase plasma conc of clarithromycin. Increased bioavailability of digoxin.
A02BC01 - omeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
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