Disorders of decreased GI motility eg, gastroparesis or ileus; GERD & dyspepsia; nausea & vomiting associated w/ various GI disorders, migraine, post-op & cancer therapy. Stimulate gastric emptying during radiographic exam, facilitate intubation of small bowel, management of aspiration syndromes.
Adult & childn 15-19 yr & weighing ≥60 kg 10 mg tid; 15-19 yr, weighing 30-59 kg & 9-14 yr (≥30 kg) 5 mg tid; 5-9 yr (20-29 kg) 2.5 mg tid; 3-5 yr (15-19 kg) 2 mg bid-tid; 1-3 yr (10-14 kg) 1 mg bid-tid; <1 yr (≤10 kg) 1 mg bid. Nausea & vomiting associated w/ cancer chemotherapy Loading dose: 2-4 mg/kg as continuous IV infusion over 15-20 min, followed by a maintenance dose of 3-5 mg/kg over 8-12 hr. Alternative: Initially up to 2 mg/kg by IV infusion over at least 15 min, repeated every 2-3 hr. Max: 10 mg/kg/day, either continuous or intermittent infusion.
Stimulation of muscular contraction in GI hemorrhage, obstruction, perforation or immediately after surgery. Hypertensive crisis in pheochromocytoma. Epilepsy, Parkinson's disease, history of depression. Review regularly patients in prolonged therapy. May affect ability to drive or operate machinery. Renal impairment. Childn. Elderly.
Extrapyramidal symptoms as acute dystonic reactions (in young adult & childn, especially if female). Parkinsonism & tardive dyskinesia in elderly on prolonged therapy. Restlessness, drowsiness, diarrhea; hypotension, dizziness, headache, depression; blood disorders, hypersensitivity reactions, neuroleptic malignant syndrome; cardiac conduction disorders; galactorrhea or related disorders. Transient increases in plasma aldosterone conc.
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