Meton Adverse Reactions

Fluid and Electrolyte Disturbances: Sodium retention, congestive heart failure in susceptible patients, hypertension, fluid retention, potassium loss, hypokalemic alkalosis.
Musculoskeletal: Muscle weakness, loss of muscle mass, steroid myopathy, osteoporosis, tendon rupture, particularly of the Achilles tendon, vertebral compression fractures, aseptic necrosis of femoral and humeral heads, pathologic fracture of long bones.
Gastrointestinal: Peptic ulcer with possible perforation and hemorrhage, pancreatitis, abdominal distention, ulcerative esophagitis.
Dermatologic: Impaired wound healing, petechial and ecchymoses, may suppress reactions to skin tests, thin fragile skin, facial erythema, increased sweating.
Neurological: Increased intracranial pressure with papilledema (pseudo-tumor cerebri) usually after treatment, convulsions, vertigo and headache.
Endocrine: Development of Cushingoid state, suppression of growth in children, secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness, menstrual irregularities, decreased carbohydrate tolerance, manifestations of latent diabetes mellitus, increased requirements of insulin or oral hypoglycemic agents in diabetics, ophthalmic, posterior subcapsular cataracts, increased intraocular pressure, glaucoma, exophthalmos, negative nitrogen balance due to protein catabolism.