Decreased blood conc w/ aspirin. Increased risk of stomach & intestinal bleeding w/ phenylbutazone, indomethacin, salicylates & other NSAIDs (eg, mefenamic acid, naproxen, diclofenac, ketoprofen); anticoagulants (eg, warfarin, dicumarol) or thrombolytics (eg, streptokinase); corticosteroids (eg, prednisone, prednisolone), SSRIs (eg, citalopram, escitalopram, sertraline). Acute reduction in kidney function & BP response to ACE inhibitors (eg, captopril, enalapril, ramipril, imidapril, fosinopril, lisinopril). May reduce the effect of mifepristone (do not use 8-12 days after mifepristone); diuretics (eg, furosemide & thiazide). Risk of methotrexate & lithium toxicity. Increased plasma concentration of cardiac glycosides (eg, digitalis). May enhance the effect of phenytoin. Increased risk of nephrotoxicity w/ ciclosporin or tacrolimus.
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