Treatment of severe systemic infections due to sensitive gm -ve & other organisms including biliary tract infections (acute cholecystitis or cholangitis), brucellosis, cat scratch disease, cystic fibrosis, endocarditis (treatment & prophylaxis of endocarditis due to streptococci, enterococci or staphylococci), endometritis, gastroentiritis, granuloma inguinale, listeriosis, meningitis, otitis externa & media, pelvic inflammatory disease, peritonitis, plague, pneumonia, septicemia, skin infection eg, in burns or ulcers (given systemically for pseudomonal & other gm -ve infections), tularemia & UTI (acute pyelonephritis). Prophylaxis of surgical infection & treatment of immunocompromised patients & those in intensive care.