Luprolex Description

Each vial contains 1.88 mg, 3.75 mg or 11.25 mg leuprorelin acetate as lyophilized microspheres.
Leuprorelin is a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH or LH-RH). The analog possesses greater potency than the natural hormone.
Reconstituted solution: White suspension which on standing deposits a white sediment which is readily re-suspended on shaking.
1.88 mg and 3.75 mg: Leuprorelin is a long-acting GnRH analog. A single monthly injection of leuprorelin acetate (Luprolex) 1.88 mg or 3.75 mg results in an initial stimulation followed by a prolonged suppression of pituitary gonadotropins.
Repeated dosing at monthly intervals results in decreased secretion of gonadal steroids; consequently, tissues and functions that depend on gonadal steroids for their maintenance become quiescent. This effect is reversible on discontinuation of drug therapy.
Leuprorelin (Luprolex) is not active when given orally. Intramuscular injection provides plasma concentrations of leuprolide over a period of one month.
11.25 mg: Leuprorelin is a long-acting GnRH analog. A single monthly injection of Leuprorelin (Luprolex) 11.25 mg results in an initial stimulation followed by a prolonged suppression of pituitary gonadotropins.
Repeated dosing at quarterly intervals results in decreased secretion of gonadal steroids; consequently, tissues and functions that depend on gonadal steroids for their maintenance become quiescent. This effect is reversible on discontinuation of drug therapy.
Leuprorelin (Luprolex) is not active when given orally. Intramuscular injection provides plasma concentrations of leuprolide over a period of three months.