Mild/moderate ear/nose/throat infection Adult 500 mg every 12 hr or 250 mg every 8 hr.
Ped >3 mth 25 mg/kg day in divided doses every 12 hr or 20 mg/kg/day every 8 hr.
Severe skin/skin structure & genitourinary tract infection & mild/moderate or severe lower resp infection Adult 875 mg every 12 hr or 500 mg every 8 hr.
Ped >3 mth 45 mg/kg/day in divided doses every 12 hr or 40 mg/kg/day in divided doses every 8 hr.
Mild/moderate or severe lower resp infection Adult 875 mg every 12 hr or 500 mg every 8 hr.
Ped >3 mth 45 mg/kg/day in divided doses every 12 hr or 40 mg/kg daily in divided doses every 8 hr.
H. pylori infection Adult Triple therapy: Amoxicillin 1 g + clarithromycin 500 mg + omeprazole 20 mg all given every 12 hr for 10 days. Dual therapy: Amoxicillin 1 g + lansoprazole 30 mg each given every 8 hr for 14 days.
Renal impairment CrCl 10-30 mL/min Adult & childn ≥40 kg 250 or 500 mg every 12 hr,
<40 kg 15 mg/kg daily in divided doses every 12 hr;
CrCl <10 mL/min Adult & childn ≥40 kg 250 or 500 mg every 24 hr,
<40 kg 15 mg/kg as single daily dose.
Hemodialysis 250 or 500 mg every 24 hr.
Neonates & infants ≤3 mth 20-30 mg/kg daily in divided doses every 12 hr.
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