Chemotherapy induced nausea & vomiting (CINV) Adult Prevention: 1-3 mg (10-40 mcg/kg) as slow IV inj (over 30 sec) or as IV infusion over 5 min, prior to the start of chemotherapy. Treatment: 1-3 mg (10-40 mcg/kg) as slow IV inj (over 30 sec) or as IV infusion over 5 min. Further doses may be administered at least 10 min apart if required. Max: 9 mg over 24 hr.
Ped Prevention & treatment: 10-40 mcg/kg (up to 3 mg) as IV infusion over 5 min prior to the start of chemotherapy. May administer 1 additional dose at least 10 min after the initial infusion w/in 24-hr period if required.
RT induced nausea & vomiting (RINV) Adult Prevention: 1-3 mg (10-40 mcg/kg) as slow IV inj (over 30 sec) or IV infusion over 5 min, prior to the start of RT.
Post-op nausea & vomiting (PONV) Adult Prevention: 1 mg (10 mcg/kg) as slow IV inj (over 30 sec) prior to induction of anesth. Treatment: 1 mg (10 mcg/kg) as slow IV inj (over 30 sec). Max total dose: 3 mg.