History of allergic conditions. Concomitant use w/ NSAIDs including COX-2 selective inhibitors, oral corticosteroids, anticoagulants eg, warfarin, SSRIs, antiplatelet agents eg, aspirin, diuretics. Discontinue use if GI bleeding, ulceration or perforation occurs. Patients w/ GI symptoms or history of GI disease (ulcerative colitis, Crohn's disease) & toxicity. Monitor digestive disturbances, especially GI bleeding. History of oesophagitis, gastritis &/or peptic ulcer. Monitor fluid retention & oedema in patients w/ a history of HTN &/or mild to moderate CHF. Patients w/ uncontrolled HTN, CHF, established ischaemic heart disease, peripheral arterial disease &/or cerebrovascular disease. Risk factors for CV disease (eg, HTN, hyperlipidaemia, DM, smoking). Mild to moderate hepatic dysfunction & mildly impaired renal function. Not intended for long-term use. May impair ability to drive or operate machinery. Women attempting to conceive. Pregnancy (1st & 2nd trimester). Childn. Elderly. Inj: Increased risk of arterial thrombotic events (eg, MI or stroke). Serious skin reactions, some are fatal including exfoliative dermatitis, SJS & TEN. Discontinue use if first appearance of skin rash, mucosal lesions occur. Patients suffering from haematopoietic disorders, SLE or mixed connective tissue disease. Soft tissue & bacterial infections. Alcoholism. May impair female fertility. Patients w/ liver disease or epilepsy.
Sign Out
