Management of HTN particularly in patients who develop cough w/ ACE inhibitors & to reduce the risk of stroke in patients w/ left ventricular hypertrophy & in the treatment of diabetic nephropathy. 50 mg tab: Management of heart failure.
HTN 50 mg once daily, may be increased to 100 mg daily based on BP response in 1 or 2 divided doses. Patient w/ intravascular vol depletion (those treated w/ high-dose diuretics) Initially 25 mg daily. Elderly >75 yr Initially 25 mg once daily. Diabetic nephropathy Initially 50 mg once daily, increased to 100 mg once daily depending on BP.
Reduced levels of active metabolite w/ rifampin & fluconazole. Increased serum K w/ K-sparing diuretics (eg, spironolactone, triamterene, amiloride), K supplements or salt containing K. Attenuated antihypertensive effect w/ NSAID indomethacin.
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