Jovia

Jovia

escitalopram

Manufacturer:

UNILAB, Inc

Distributor:

UNILAB, Inc
Concise Prescribing Info
Contents
Escitalopram oxalate
Indications/Uses
Major depressive disorder (MDD). Obsessive-compulsive disorder (OCD). Panic disorder w/ or w/o agoraphobia. Generalized anxiety disorder (GAD). Social anxiety disorder (social phobia).
Dosage/Direction for Use
MDD Adult 10 mg once/day, increased to max of 20 mg/day for 1 wk; adolescent 10 mg once/day for 3 wk. Maintenance: Continue dose for 6 mth. GAD Adult 10 mg once/day, may increased to 20 mg/day for 1 wk. Maintenance: 20 mg/day for 6 mth. OCD Adult 10 mg once/day, may be increased to 20 mg/day. Social anxiety disorder Adult 10 mg once/day, may be decreased/increased to 20 mg/day for 12 wks. Panic disorder w/ or w/o agoraphobia Adult 5 mg 1st wk, increase to 10 mg/day, max: 20 mg/day for 3 mth. Elderly Initially, 5 mg once/day may be increased to 10 mg/day. Patients w/ mild to moderate hepatic insufficiency 5 mg/day.
Administration
May be taken with or without food: Take in the morning or evening.
Contraindications
Hypersensitivity to citalopram or escitalopram. Serotonin syndrome w/ MAOI. QT interval prolongation w/ pimozide.
Special Precautions
Risk of suicide attempt; adult & ped may experience worsening of depression &/or emergence of suicidal ideation & behaviour. Paradoxical anxiety. Screening of patients for bipolar disorder. Potential for abuse, tolerance or physical dependence. Activation of mania/hypomania & bipolar disorder. Caution w/ electroconvulsive therapy. Development of akathisia/psychomotor restlessness. Seizures. Serotonin syndrome/NMS-like events. Reversible cerebral vasoconstriction syndrome (thunderclap headache). Abnormal bleeding. Angle closure glaucoma. Increased risk of bone fracture. Hyponatremia. Patients w/ cardiac disease; QT interval prolongation & torsades de pointes; diabetic patients. Avoid abrupt discontinuation. May impair judgement skills, may affect ability to drive or operate machinery. Pregnancy (category C) & lactation. Childn & elderly.
Adverse Reactions
Abscess, appendicitis, bronchitis acute, atrophic vaginitis, bronchitis viral, carbuncle, cellulitis, cystitis, dental caries, ear infection, erysipelas, eye infection, folliculitis, fungal infection, furuncle, GI infection, gastroenteritis, genital infection, genitourinary chlamydia infection, gingival infection, hepatitis, hepatitis fulminant, herpes simplex, herpes zoster, impetigo, infection (bacterial, fungal, parasitic, viral), infection TB, flu, laryngitis, lung infection, mastitis, moniliasis, moniliasis genital, nasopharyngitis, onychomycosis, otitis externa, otitis media, pelvic inflammatory disease, peritonsillar abscess, pharyngitis, pharyngitis streptococcal, pneumonia, pyelonephritis acute, resp tract infection, salmonellosis, sinusitis, skin infection, staphylococcal infection, streptococcal infection, tracheitis, tooth abscess, tonsillitis, tooth infection, UTI, vag candidiasis, vag infection, vaginitis, varicella, viral infection, viral upper resp tract infection, vulvovaginal mycotic infection, wound infection. Breast neoplasm, benign breast neoplasm, cyst, cyst ovarian, lipoma, marrow hyperplasia, skin papilloma, uterine fibroid, uterine leiomyoma. Agranulocytosis, anemia (aplastic, hemolytic, hypochromic); bleeding abnormal predominantly of the skin and mucous membranes, including purpura, epistaxis, hematoma, vag bleeding, and GI bleeding; hematoma, idiopathic thrombocytopenia purpura, leukocytosis, leukopenia, lymphadenopathy, lymphadenitis, thrombocytopenia. Allergic edema, allergic reactions, seasonal/aggravated allergy, anaphylactic reaction, angioedema, house dust allergy, epidermal necrolysis, hypersensitivity, SJS. Goiter, hyperprolactinemia, hyperthyroidism, SIADH, thyroiditis. Anorexia, decreased/increased appetite, carbohydrate craving, dehydration, DM, fluid retention, food craving, abnormal glucose tolerance, gout, hypercholesterolemia, hyperglycemia, hyperlipemia, hypermagnesemia, hyperphagia, hypoglycemia, hyponatremia, latent tetany, thirst, xerophthalmia. Abnormal dreams, agitation, aggression, anger, anxiety, apathy, bruxism, concentration impairment, confusional state, crying, delirium, delusion, depersonalization, depression, depression aggravated, derealization/feeling unreal, disorientation, early morning awakening, emotional disorder, emotional distress, emotional lability, excitability, euphoric mood, flat affect, forgetfulness, generalized anxiety disorder, hallucination (auditory, visual), hypomania, indifference, insomnia, jitteriness, lethargy, irritability, major depression, mania, mental disorder, middle insomnia, mood swings, nervousness, nightmare, OCD, panic attack, panic reaction, paranoia, paroniria, psychomotor retardation, psychosis acute, restlessness, psychomotor/aggravated restlessness, self-harm or thoughts of self-harm, sleep disorder, snoring, suicidal behavior, suicidal ideation, suicide attempt, suicide completed, suicidal tendency, tension, tic, abnormal thinking. Amnesia, akathisia, ataxia, balance disorder, burning sensation, carpal tunnel syndrome, CVA, choreoathetosis, clonic convulsion, coma, coordination abnormal, dizziness, dizziness postural, disturbance in attention, dysarthria, disequilibrium, dysesthesia, dysgeusia, dysphasia, dystonia, extrapyramidal disorder, facial palsy, facial paresis, facial spasm, grand mal convulsion, head discomfort, headache, hyperkinesia, hyperreflexia, hypersomnia, hypertonia, hypoesthesia, hypogeusia, lethargy, light headedness, loss of consciousness, memory impairment, migraine, muscle contractions involuntary, movement disorder, myoclonus, nerve root lesion, NMS, neuralgia, neuralgia ischial, neuropathy, nystagmus, paralysis, paresthesia, Parkinsonism, petit mal epilepsy, psychomotor hyperactivity, restless legs syndrome, sciatica, sedation, sensory disturber, sleep talking, somnolence, speech disorder, tardive dyskinesia, taste disturbance, tension headache, tetany, tics, tremor, twitching, vasovagal attack. Accommodation disorder, amblyopia, asthenopia, blepharospasm, conjunctivitis, chromatopsia, diplopia, dry eyes, eye hemorrhage, eye irritation, eye pain, eye pruritus, eye swelling, eyelid edema, iritis, keratoconus, mydriasis, myopia, night blindness, ocular hemorrhage, photopsia, retinal detachment, scotoma, vision abnormal, vision blurred, visual disturbance, vitreous detachment. Cerumen impaction, deafness, ear disorder, ear pain, earache, Meniere's disease, motion sickness, otosalpingitis, tinnitus, tympanic membrane perforation, vertigo. Angina pectoris, atrial fibrillation, atrial ventricular block first degree, bradycardia, cardiac arrest, cardiac failure, chest pain, chest tightness, extrasystoles, MI, myocardial ischemia, myocarditis, nodal rhythm, palpitations, sinus bradycardia, syncope, syncope vasovagal, tachycardia, torsade de pointes, ventricular arrhythmia, ventricular tachycardia. Cerebrovascular disorder, circulatory collapse, flushing, hematoma, hot flush, HTN, hypotension, orthostatic hypotension, pallor, peripheral coldness, peripheral ischemia, varicose vein, vein disorder, vein distended. Asthma, choking, cough, dysphonia, dyspnea, epistaxis, hyperventilation, nasal congestion, nasal polyps, pharyngolaryngeal pain, postnasal drip, pulmonary embolism, pulmonary HTN of the newborn, URTI, allergic/perennial rhinitis, rhinorrhea, shortness of breath, sleep apnea, sinus congestion/headache, throat irritation, throat tightness, tracheal disorder, tracheitis, wheezing, yawning. Abdominal cramp, abdominal discomfort, abdominal distension, abdominal pain upper, anal fissure, belching, bloating, bowel movements frequent, colitis, colitis ulcerative, colonic polyp, constipation, Crohn's disease, diarrhea, dry mouth, dysphagia, dyspepsia, enteritis, epigastric discomfort, eructation, flatulence, food poisoning, gastritis, GERD, GI pain, gastritis, GI hemorrhage, gingival bleeding, gingival pain, heartburn, hematemesis, hematochezia, hemorrhoids, ileitis, indigestion, imitable bowel syndrome, lip dry, melena, nausea, oral pain, pancreatitis, periodontal destruction, pruritus ani, rectal hemorrhage, reflux gastritis, stomach discomfort, stomatitis, stool frequency increased, taste perversion, taste alteration, tongue black hairy, tongue disorder, toothache, tooth disorder, tooth erosion, ulcerative stomatitis, vomiting. Hepatic failure, hepatic necrosis. Acne, alopecia, cold sweat, dermal cyst, dermatitis, (acneiform, allergic, atopic, contact, fungal, hand, lichenoid), dry skin, ecchymosis, eczema, furunculosis, hyperhidrosis, increased tendency to bruise, ingrown nail, night sweats, photosensitivity reaction, pruritus, rash (erythematous, maculopapular, pustular), psoriasis aggravated, skin disorder, skin irritation, skin nodule, skin odor abnormal, skin warm, urticaria, verruca. Arthralgia, arthritis, arthropathy, arthrosis, bursitis, costochondritis, exostosis, fasciitis plantar, fibromyalgia, finger deformity, ganglion, intervertebral disc protrusion, jaw stiffness, joint stiffness, leg cramps, muscle contracture, muscle cramps, muscle spasms, muscle tightness, muscle twitching, muscle weakness, musculoskeletal chest pain, musculoskeletal discomfort, musculoskeletal pain, musculoskeletal stiffness, myalgia, myopathy, neck pain, OA, osteoporosis, plantar fasciitis, rhabdomyolysis, RA, sensation of heaviness, tendon disorder, tendinitis, tenosynovitis, trismus. Bladder dilatation, bladder discomfort, chromaturia, cystitis, dysuria, hematuria, micturition disorder, micturition frequency, micturition urgency, nocturia, pollakiuria, polyuria, renal calculus, renal failure acute, renal pain, urinary frequency, urinary hesitation, urinary incontinence, urinary retention. Unintended pregnancy, spontaneous abortion. Amenorrhea, anorgasmia, breast discharge, breast pain, breast tenderness, dysmenorrhea, ejaculation delayed, epididymitis, erectile disorder, erectile dysfunction, ejaculation failure, galactorrhea, genital pain, intermenstrual bleeding, libido decreased/increased, loss of libido, menopausal symptoms, menstrual cramps, menstrual disorder, menorrhagia, menometrorrhagia, menstruation irregular, metrorrhagia, orchitis noninfective, orgasm abnormal, painful erection, pelvic pain, premenstrual syndrome, PMT, priapism, postmenopausal hemorrhage, prostatic disorder, sexual dysfunction, sexual function abnormality, testicular pain, uterine spasm, vag discharge/hemorrhage. Epidermal nevus, Gilbert's syndrome. Asthenia, back pain, chest wall pain, chest discomfort, chest pain, chills, death, edema, edema extremities, edema face, edema peripheral pain, fatigue, feeling abnormal, feeling hot, feeling jittery, gait abnormal, hernia, hunger, irritability, leg pain, limb pain, local swelling, malaise, neck pain, pain in extremity, pain in jaw, performance status decreased, pyrexia, resp sighs, rigors, satiety early, sensation of blood flow, shoulder pain, sluggishness, thirst. Increased AST/ALT, arthroscopy, blood alkaline phosphatase increased, blood bilirubin increased/decreased, blood cholesterol increased, blood glucose increased, BP increased, blood uric add increased, blood urine present, drug level increased, body temp increased, ECG PR shortened, ECG QT prolonged, heart rate increased, Hb decreased, hepatic enzyme increased, INR increased, LFT abnormal, neurotransmitter level altered, platelet count decreased, pregnancy test +ve, PT decreased, wt increased/decreased. Ankle fracture, arthropod bite, arthropod sting, bite, bite animal, bum, concussion, contusion, electrical shock, excoriation fall, facial bones fracture, food poisoning, foot fracture, fractured neck of femur, injury (accidental, back, eye, joint, inflicted, ligament, limb, lumbar disc lesion, mouth, neck, sports, tooth, whiplash), intentional overdose, joint dislocation, joint sprain, muscle rupture, post-traumatic pain, procedural pain, radius fracture, rib fracture, road traffic accident, skin laceration, sting poisoning, sunburn, thermal bum, ulna fracture. Colon polypectomy, gingival op, scar excision, surgical intervention, tooth extraction. Alcohol problem, drug abuse, family stress, stress at work.
Drug Interactions
Contraindicated w/ MAOIs, moclobemide, linezolid, selegiline; QT prolongation w/ class IA & III antiarrythmics, antipsychotics (eg, phenothiazine derivatives, pimozide, haloperidol), TCA, antimicrobials (eg, sparfloxacin, moxifloxacin, erythromycin IV, pentamidine, halofantrine; astemizole, mizolastine. Not recommended w/ other psychotropic drugs, alcohol; enhanced side effects w/ lithium & tryptophan; increased incidence of adverse effects w/ St John's wort; may lead to serotonin syndrome w/ tramadol, sumatriptans & other triptans. May potentiate risk of bleeding w/ NSAID or aspirin. Lowering seizure threshold w/ antidepressants, neuroleptics, mefloquine, bupropion, & tramadol. CNS effects w/ other centrally acting drugs. Increased risk of malignant arrhythmias w/ drugs inducing hypokalemia/hypomagnesemia. Monitor side effects when used w/ omeprazole, esomeprazole, fluvoxamine, lansoprazole, ticlopidine or cimetidine; Caution is recommended when concomitantly used w/ flecainide, propafenone, metoprolol, or some CNS acting drugs eg, antidepressants or antipsychotics. Increased in plasma levels w/ desipramine or metoprolol.
MIMS Class
Antidepressants
ATC Classification
N06AB10 - escitalopram ; Belongs to the class of selective serotonin reuptake inhibitors. Used in the management of depression.
Presentation/Packing
Form
Jovia FC tab 20 mg
Packing/Price
28's
Form
Jovia FC tab 10 mg
Packing/Price
28's (P52.22/tab, P1,462.03/pack)
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