Myelofibrosis Platelet count >200,000/mm3 Recommended starting dose: 20 mg bid;
platelet count between 100,000/mm3 & 200,000/mm3 15 mg bid;
platelet count between 50,000/mm3 & 100,000/mm3 Max: 5 mg bid. Dose reductions should be considered if the platelet counts decrease <100,000/mm
3. Max dose: 25 mg bid.
Polycythemia vera & graft-versus-host disease Initially 10 mg bid. For polycythemia vera, dose reduction should be considered if Hb decreases 10-12 g/dL. Max dose: 25 mg bid.
Severe renal impairment Myelofibrosis Starting dose based on platelet count should be reduced by approx 50%.
Polycythemia vera 5 mg bid.
Patients w/ ESRD on hemodialysis Myelofibrosis Initially 15 or 20 mg based on platelet counts w/ subsequent single doses only after each dialysis session.
Polycythemia vera 10 mg or 2 doses of 5 mg given 12 hr apart administered post-dialysis & only on the day of haemodialysis.
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