Initially 0.5-1 mg/kg once daily or 2 divided doses. May adjust dose after 4 wk up to 1 mg/kg daily according to response & side effects. Patient intolerant to the initial dose Continue treatment at 0.1-0.2 mg/kg daily. Doses up to 2 mg/kg daily are permitted whose disease is very severe or primarily on the body instead of the face. Duration: 12-20 wk or until the total cyst count decreased by 70%.
Patients receiving isotretinoin should not donate blood during or for 1 mth after cessation of therapy. History of depression; monitor for signs of depressive illness. Measure liver function & fasting blood lipids after the 1st mth & thereafter. Monitor blood glucose throughout treatment in patients who either have, or are predisposed to DM. May experience reduced tolerance to contact lenses. Avoid excessive exposure to sunlight & UV light. Avoid pregnancy during treatment & for 1 mth after treatment has been w/drawn.
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