Patients presenting a risk factor, particularly those w/ WHO performance status 2. Increased risk of delayed diarrhea especially in patients w/ previous abdominal/pelvic radiotherapy, baseline hyperleukocytosis, performance status ≥2 & women. Infections & hematological toxicity. Prophylactic treatment w/ antiemetic before each treatment is recommended. Prophylactic treatment w/ atropine sulfate in acute or severe cholinergic syndrome. Acute cholinergic syndrome. Renal impairment. Treat bowel obstruction before therapy. Renal insufficiency, hypotension or circulatory failure. Perform complete blood cell counts; liver function tests at baseline & before each cycle. Take contraceptive measures during & for at least 3 mth after cessation of therapy. Women of childbearing potential. Minor or moderate influence on the ability to drive & use machine. Elderly.
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 20 mg_mL50cb65bd-0e63-422f-82e8-abfe00e1b7d1.GIF)
