Hyos Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Action Indications/Uses Dosage/Direction for Use Special Precautions Adverse Reactions MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Hyoscine-N-butylbromide

Indications/Uses

Tab: Symptomatic relief of abdominal pain, cramps & discomfort including menstrual cramps, spasm of the biliary system & urinary tract. Symptomatic relief of irritable bowel syndrome (IBS). Inj: Symptomatic relief of GI & genitourinary disorders characterized by smooth muscle spasms. Spasm of the biliary system. Irritable bowel syndrome (IBS). Aids to produce smooth muscle relaxation prior to radiological or diagnostic procedures eg, gastroduodenal endoscopy.

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Dosage/Direction for Use

Tab Adult & adolescent >12 yr Usual dose: 1-2 tab every 4-6 hr. IBS Initially 1 tab tid, may be increased if further relief is necessary. Childn 6-12 yr Usual dose: 1 tab tid. Slow IV/IM/SC inj Adult & adolescent >12 yr 20-40 mg several times a day. As a continuous infusion of 5 mg/hr for up to 4 days. Max: 100 mg/day. Infant & childn up to 12 yr Severe cases 0.3-0.6 mg/kg several times a day. Max: 1.2 mg/kg/day.

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Administration

May be taken with or without food.

Special Precautions

Patients w/ Down's syndrome, hepatic or renal disease & hyperthyroidism, conditions characterized by tachycardia, gastric ulcer, GERD, hiatal hernia reflux esophagitis, autonomic neuropathy, partial obstructive uropathy & diarrhea, those w/ known or suspected GI infections eg, C. difficile-associated diarrhea & colitis, shigellosis & dysentery, mild to moderate ulcerative colitis, pyrexia. Increased IOP. Anaphylaxis has been reported after parenteral administration.

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Adverse Reactions

Xerostomia, dry skin, accommodation disorders, blurred vision, cycloplegia, mydriasis, photophobia, anhidrosis, urinary hesitancy & retention, transient bradycardia (followed by tachycardia, hypotension, palpitations & arrhythmia), reduced bronchial secretions, xerophthalmia, & constipation.

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Action

View Hyos mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Antispasmodics

ATC Classification

A03BB01 - butylscopolamine ; Belongs to the class of belladonna alkaloids, semisynthetic, quaternary ammonium compounds. Used in the treatment of functional gastrointestinal disorders.

Regulatory Classification

Presentation/Packing

Form

Hyos FC tab 10 mg

Packing/Price

100's

Form

Hyos inj 20 mg/mL

Packing/Price

(amp) 2 mL x 10 × 1's

Hyos

hyoscine

Manufacturer:

Amherst Lab

Distributor:

UNILAB, Inc