Treatment of herpes simplex infections Adult 200 mg 5 times daily at approx 4 hr intervals omitting the night time dose for 5-10 days.
Severely immunocompromised or w/ impaired gut absorption Dose can be doubled to 400 mg or IV dosing may be considered. Begin as early as possible after the start of an infection, for recurrent episodes this should be during the prodromal period or when lesions 1st appear.
Treatment of varicella & herpes zoster infections 800 mg every 4 hr for 7 days.
Childn <2 yr ½ adult dose.
Treatment of varicella infections Childn >6 yr 800 mg qid for 5 days,
<2 yr 200 mg qid for 5 days.
Patient w/ renal impairment (CrCl <10 mL/min) 200 mg bid at approx 12 hr intervals.
Suppression of herpes simplex infections in immunocompetent patient Adult 200 mg qid at approx 6 hr intervals or 400 mg at approx 12 hr intervals. May titrate dose down to 200 mg tid at approx 8 hr intervals or even bid at approx 12 hr intervals. Therapy should be interrupted at intervals of 6-12 mth.
Prophylaxis of herpes simplex infections in immunocompromised patient 200 mg qid at approx 6 hr intervals.
Severely immunocompromised patient (eg, after bone marrow transplant) w/ impaired gut absorption May double the dose to 400 mg 6 hrly or IV dosing may be considered.
Childn <2 yr ½ adult dose.
Treatment of herpes zoster infections 800 mg 5 times daily at approx 4 hr intervals, omitting the night dose for 7 days.
Severely immunocompromised or w/ impaired gut absorption IV dosing may be considered. Dosing should begin as early as possible after the start of an infection (after rash onset).
Patient w/ renal impairment (CrCl <10 mL/min) 800 mg tid-qid at approx 6-8 hr intervals.
Treatment of chickenpox Childn ≤2 yr 20 mg/kg qid for 5 days. Dosing should begin as early as possible after the start of a chicken pox rash (24 hr after rash onset).
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