Granules: Treatment of concomitant disease & sequelae due to impaired hepatic detoxification activity eg, cirrhosis of the liver w/ the symptoms of latent & manifest hepatic encephalopathy. Infusion: Treatment of hyperammonemia due to acute or chronic liver disease eg, liver cirrhosis, fatty liver, hepatitis; for the treatment of incipient disturbances of consciousness (pre-coma) or neurological complications (hepatic encephalopathy).
Granules 1-2 sachet up to tid. Infusion Up to 4 amp daily. W/ incipient clouding of consciousness (pre-coma) or clouding of consciousness (coma) Up to 8 amp/24 hr, depending on the severity of the condition. Max infusion rate: 5 g/hr. Venous tolerance: Should not exceed 6 amp should be dissolved per 500 mL infusion.
May impair ability to drive & use machines. Avoid use during pregnancy & lactation. Childn. Granules: Should not be given in patients w/ rare hereditary problems of fructose intolerance. DM. Long-term use may be harmful to the teeth (caries). Infusion: Monitor serum & urine urea levels at high doses. Infusion rate must be adjusted if w/ substantially impaired liver function to prevent nausea & vomiting.
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