Recommended dose: 75 mg/m2 administered over 1 hr every 3 wk. Patients must be premed w/ oral corticosteroids eg, dexamethasone 16 mg/day for 3 days starting 1 day prior to docetaxel administration.
Closely monitor main function index during infusion. Monitor leukocyte counts frequently. Decrease dosage in case of severe neutropenia (<500 cells/mm3 & duration of ≥7 days) & severe peripheral neurotoxicity. Discontinue therapy if severe hypersensitivity reactions eg, decrease BP by >20 mmHg, bronchospasm or eruption/erythema; & cutaneous reactions eg, localized erythema of extremities, edema & desquamation occur. Childn.
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