Bone marrow suppression manifested as neutropenia, leukopenia, anemia, thrombocytopenia w/ associated infections. New onset or worsening of preexisting peripheral neuropathy. GI toxicities manifested as anorexia, nausea, vomiting, diarrhea, constipation & stomatitis. Fatigue, alopecia, increased liver enzymes, sepsis & musculoskeletal pain syndrome. Decreased appetite; headache; dyspnea, cough; arthralgia & myalgia, back pain, pain in extremity; asthenia, pyrexia; decreased wt.