Treatment & control of bleeding esophageal varices. Treatment of type 1 hepatorenal syndrome characterized by spontaneous acute renal insufficiency in patients suffering from severe cirrhosis w/ ascites.
Bleeding esophageal varicesAdult Initially 2 mg IV inj every 4 hr. Maintain treatment until bleeding is controlled for 24 hr up to max 48 hr. After the initial dose, may adjust to 1 mg IV every 4 hr in patient w/ body wt <50 kg or if adverse effects occur. Type 1 hepatorenal syndrome 3-4 mg every 24 hr as 3 or 4 administrations. Standard ave duration of treatment: 10 days.
Increased hypotensive effect of nonselective β-blockers on the portal vein. May lower the heart rate & cardiac output w/ bradycardic drugs eg propofol, sufentanil.
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