Additional therapy in association w/ diet in patient w/ DM. Prevention of onset of type 2 diabetes in individuals w/ confirmed impaired glucose tolerance, in combination w/ diet & exercise.
AdultAdditional therapy in association w/ diet in patients w/ DM Initially 3x 1 tab of 50 mg/day or 3x ½ tab of 100 mg/day up to 3x 2 tab of 50 mg/day or 3x 1 tab of 100 mg/day. Further increase to 3x 200 mg acarbose/day if necessary. Prevention of type 2 diabetes w/ impaired glucose tolerance Initially 50 mg once daily then increase to 3x 1 tab of 100 mg/day w/in 3 mth.
Should be taken with food: Swallow whole w/ a little liqd directly before meal, or chew w/ 1st few mouthfuls of the meal.
Contraindications
Hypersensitivity. Chronic intestinal disorders associated w/ distinct disturbances of digestion & absorption; states which may deteriorate as a result of increased intestinal gas formation (eg, Roemheld's syndrome, major hernias, intestinal obstruction & ulcers). Patients w/ severe renal impairment (CrCl <25 mL/min).
Increased carbohydrate fermentation in the colon w/ sucrose & foods containing sucrose may result to GI dsicomfort. Fall of blood glucose values into hypoglycaemic range w/ sulphonylurea, metformin or insulin; hypoglycaemic shock may occur in individual cases. Use glucose instead of sucrose if acute hypoglycaemia develops. May affect digoxin bioavailability. May possibly influence action of acarbose w/ cholestyramine, intestinal adsorbents & digestive enzyme products. Enhanced reductions of postprandial blood glucose & increased frequency & severity of GI side effects w/ oral neomycin (temporary dose reduction is considered).
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